Visualization of a dopamine D1 receptor mRNA in human and rat brain
Identifieur interne : 004691 ( Main/Exploration ); précédent : 004690; suivant : 004692Visualization of a dopamine D1 receptor mRNA in human and rat brain
Auteurs : G. Mengod [Suisse] ; M. T. Vilar [Suisse] ; H. B. Niznik [Canada] ; R. K. Sunahara [Canada] ; P. Seeman [Canada] ; B. F. O'Dowd [Canada] ; J. M. Palacios [Suisse]Source :
- Molecular Brain Research [ 0169-328X ] ; 1991.
Abstract
Using 32P-labeled oligonucleotides derived from the coding region of human dopamine D1 receptor mRNA we have localized in the human and rat brain the cells containing the mRNAs coding for this receptor. Dopamine D1 receptor mRNA in human brain was found to be contained in the neurons of the caudate and putamen nuclei as well as in the nucleus accumbens, some cortical regions and some nuclei of the amygdala. In the rat brain, cells containing D1 receptor mRNA were enriched in caudate-putamen and accumbens nuclei, olfactory tubercle, islands of Calleja, some cortical areas and in several thalamic nuclei. Moreover, in both species, it was absent from the neurons of the substantia nigra both pars compacta and pars reticulata and ventral tegmental area as well as from the globus pallidus pars lateralis and medialis in human and globus pallidus and entopeduncular nucleus in rat. In general, a good agreement was found with the distribution of binding sites labeled with the D1 antagonist SCH 23390. The main exception was the absence of D1 receptor mRNA in globus pallidus and substantia nigra, regions where high densities of receptor sites are found. These data support the notion that sites in these two regions are localized to projections from striatal neurons and that dopaminergic neurons do not express this receptor.
Url:
DOI: 10.1016/0169-328X(91)90110-J
Affiliations:
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Palacios</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Preclinical Research, Sandoz Pharma Ltd.</wicri:regionArea><wicri:noRegion>Sandoz Pharma Ltd.</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Brain Research</title><title level="j" type="abbrev">BRESM</title><idno type="ISSN">0169-328X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="185">185</biblScope><biblScope unit="page" to="191">191</biblScope></imprint><idno type="ISSN">0169-328X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0169-328X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using 32P-labeled oligonucleotides derived from the coding region of human dopamine D1 receptor mRNA we have localized in the human and rat brain the cells containing the mRNAs coding for this receptor. Dopamine D1 receptor mRNA in human brain was found to be contained in the neurons of the caudate and putamen nuclei as well as in the nucleus accumbens, some cortical regions and some nuclei of the amygdala. In the rat brain, cells containing D1 receptor mRNA were enriched in caudate-putamen and accumbens nuclei, olfactory tubercle, islands of Calleja, some cortical areas and in several thalamic nuclei. Moreover, in both species, it was absent from the neurons of the substantia nigra both pars compacta and pars reticulata and ventral tegmental area as well as from the globus pallidus pars lateralis and medialis in human and globus pallidus and entopeduncular nucleus in rat. In general, a good agreement was found with the distribution of binding sites labeled with the D1 antagonist SCH 23390. The main exception was the absence of D1 receptor mRNA in globus pallidus and substantia nigra, regions where high densities of receptor sites are found. These data support the notion that sites in these two regions are localized to projections from striatal neurons and that dopaminergic neurons do not express this receptor.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Suisse</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Mengod, G" sort="Mengod, G" uniqKey="Mengod G" first="G." last="Mengod">G. Mengod</name></noRegion><name sortKey="Palacios, J M" sort="Palacios, J M" uniqKey="Palacios J" first="J. M." last="Palacios">J. M. Palacios</name><name sortKey="Vilar, M T" sort="Vilar, M T" uniqKey="Vilar M" first="M. T." last="Vilar">M. T. Vilar</name></country><country name="Canada"><region name="Ontario"><name sortKey="Niznik, H B" sort="Niznik, H B" uniqKey="Niznik H" first="H. B." last="Niznik">H. B. 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